Posted by SLS on December 27, 2014, at 1:47:15
In reply to Rozerem, posted by vbs on December 26, 2014, at 16:18:05
Has taking melatonin ever helped? I think most people are under the impression that you are supposed to take it 30 - 60 minutes before bedtime. On average, it is actually better to take it 2 - 4 hours before bedtime. Strangely enough, some people find it most helpful when taken during the afternoon. My guess is that the somnogenic effects of melatonin have more to do with circadian endocrine synchronization than acute sedation. I would not look at Roserem (ramelteon) as being a more potent form of melatonin. It might not function the same way.
The ideal time to take melatonin is variable, and might depend on the illness being treated and the schedule of drugs being taken. Experimentation is often necessary to establish the most effective parameters. It is important to avoid endocrine misalignment. We are not looking at a healthy system, so it probably does not make sense to assume that melatonin dosage and timing would follow the same pattern in illness as it does in health. Less is sometimes more. Unfortunately, the systematic study of the clinical use of melatonin is lacking. You could try taking 0.5 mg 2 hours before bedtime and work backwards if necessary. If you reach 4 hours without effect, you could then increase the dosage to 3.0 mg or higher.
http://www.ncbi.nlm.nih.gov/pubmed/20410229
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1074510
URL: http://www.dr-bob.org/babble/20141120/msgs/1074519.html