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Re: SSRI + Dexedrine, dangerous bc serotonin syndrome?

Posted by tom2228 on May 19, 2015, at 1:10:14

In reply to Re: SSRI + Dexedrine, dangerous bc serotonin syndrome? » kilo8, posted by phidippus on May 18, 2015, at 10:18:45

> There is no difference between a TCA and SSRI-both promote the release of serotonin.
>
> Eric

Eric, that's not true. A possible mechanism by which TCAs confer greater safety against serotonin syndrome is that most of them (not all) are 5-HT2a antagonists, which are used to treat SS. And they don't all necessarily promote 5-HT release -- according to Gillman, amitriptyline, for example, which is an SSRI, does not significantly increase serotonin levels.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014120/

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poster:tom2228 thread:1078643
URL: http://www.dr-bob.org/babble/20150407/msgs/1079054.html