Posted by SLS on July 7, 2015, at 22:21:56
In reply to nicotine as a medication, posted by rjlockhart37 on July 7, 2015, at 21:57:44
Linkadge has long postulated a role for nicotine or nicotinic receptors in the treatment of depression. It turns out that a metabolite of ketamine, hydroxynorketamine (HNK), targets the alpha-7 nicotinic receptor subtype without affecting NMDA receptors. It has already demonstrated antidepressant properties preclinically. I don't know if there are plans for clinical trials, though. I imagine the drug could be patented. I am now wondering if the clinical benefit produced by ketamine for depression has little to do with NMDA receptors.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1080313
URL: http://www.dr-bob.org/babble/20150629/msgs/1080314.html