Posted by SLS on July 14, 2015, at 14:35:41
In reply to AD for norepinephrine, posted by kribensis on July 14, 2015, at 13:50:37
> I think that norepinephrine is my issue
How did you come to that conclusion? Just curious.
> and I have trouble finding an AD that works. Any suggestions for ones that act mostly in norepinephrine? (Do not tolerate Wellbutrin). Also needs to be one available in Canada.
The most selective and potent NE reuptake inhibitor is desipramine (Norpramin). Nortriptyline (Pamelor) is predominantly selective for NE also. Both of these drugs are tricyclic anidepressants. Another selective NE reuptake inhibitor is atomoxetine (Strattera). However, it is a better treatment for ADHD / ADD than it is for depression.
An alternative pro-NE strategy is to block NE alpha-2 autoreceptors. Mirtazapine (Remeron) and mianserin (Athymil) both have this property. Of the two, mirtazapine is the least sedating.
Personally, I found venlafaxine (Effexor) 300 mg/day to be more effective with the addition of nortriptyline 75 mg/day. Others do better with the addition of mirtazapine to venlafaxine. Mirtazapine is a better antidepressant at doeages of 45 mg/day or higher.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1080492
URL: http://www.dr-bob.org/babble/20150629/msgs/1080493.html