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BDNF genotypes and response to different drugs

Posted by SLS on July 15, 2015, at 16:03:20

BDNF (brain-derived neurotrophic factor) is a growth hormones for neurons.

A recent study published in the Journal of Affective Disorders (April 2015) suggests that different genotypes coding for BDNF may help to determine drug choice in mood disorders. People with one type of BDNF respond better to SSRIs, while those with another type respond better to SNRIs and tricyclics. There is more work to be done to reproduce these findings. However, we are getting closer to biological tests to diagnose and determine treatments for people with mental illness.

Genotypes for the BDNF gene versus drug choice:

val66val = SSRI = 66% of people
val66met and met66met = SNRI; TCA = 33% of people

Previously, BDNF genotypes were associated with varying responses to ketamine.

val66val 65.5% = best response to ketamine
val66met 31.5% = intermediate response to ketamine
met66met 3.0% = poor-response to ketamine


- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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URL: http://www.dr-bob.org/babble/20150629/msgs/1080525.html