Posted by Uncouth on July 24, 2015, at 12:03:25
In reply to Re: PDE4 inhibitors?, posted by linkadge on July 23, 2015, at 16:49:56
Scott et al,
Check out IBUDILAST
Only available in Japan as PINATOS
CHeck out this great article my buddy who owns this blog wrote about it. I've been trying it at 40-90mg a day. Can't say it's totally working but I definitely feel better in terms of general level of inflammation. This article is talking about its effects on glial-related inflammation and addictive behaviors and depression, rather than straight up cAMP increase, though combined with Forskolin it would potentaly increase cAMP, just like the well known "CILTEP" stack used by some people on longecity (I believe artichoke extract, as well as sceletium (kanna) are also effective PDE4 inhibitors. Luteloin might be as well but there are bioavailability questions).
Forskolin reliably increases cAMP independently of PDE4 inhibition but the combination probably is the best.
http://www.metabolicalchemy.com/ibudilast-kicks-inflammation-in-the-*ss/
poster:Uncouth
thread:1080700
URL: http://www.dr-bob.org/babble/20150629/msgs/1080734.html