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Re: does lamotrigine cancel out dexedrine?

Posted by SLS on August 5, 2015, at 12:41:31

In reply to Re: does lamotrigine cancel out dexedrine? » dopamine77, posted by phidippus on August 5, 2015, at 10:15:28

> The two drugs have very different pharmocological profiles. Lamictal's mechanism of action may include an increase in dopamine, but that is unclear.
>
> Eric

My theory is that lamotrigine indirectly disinhibits dopamine release in the nucleus accumbens via glutamate release inhibition upstream. (Certain glutamatergic circuits afferent to the nucleus accumbens function to inhibit dopamine activity there).


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