Posted by Hugh on September 7, 2015, at 13:15:03
In reply to Re: Magnesium and Anxiety/Depression/etc. » Hugh, posted by herpills on September 4, 2015, at 18:43:14
No harmful interactions that I'm aware of. But it affects different people in different ways. I've read that some people take magnesium-L-threonate at bedtime as a sleep aid. If I take it late in the day, it makes it much more difficult for me to fall asleep.
Magnesium appears to act synergistically with standard antidepressants and with ketamine.
The following is from http://www.ncbi.nlm.nih.gov/pubmed/23541145
Depressed patients with low Mg(2+) levels tend to be therapy refractory. Accordingly, administration of Mg(2+) either alone or in combination with standard antidepressants acts synergistically on depression like behavior in animal models.
CONCLUSION:
On the basis of the potential pathophysiological role of Mg(2+)-regulation, it may be possible to predict the action of ketamine and of related compounds based on Mg(2+) levels. Furthermore, screening for compounds to increase neuronal Mg(2+) concentration could be a promising instrument to identify new classes of antidepressants. Overall, any discussion of the glutamatergic system in affective disorders should consider the role of Mg(2+).
poster:Hugh
thread:1082046
URL: http://www.dr-bob.org/babble/20150901/msgs/1082187.html