Posted by SLS on October 28, 2015, at 17:29:08
In reply to Re: Scott (nm), posted by ihatedrugs1 on October 28, 2015, at 15:48:43
I am sorry that your brain is so stubborn. This is, unfortunately, a very familiar situation for me.
I think your idea of trying brexpiprazole makes sense given your lack of response to Saphris and your akathisia reaction to Abilify. Brexpiprazole may very well allow you to take dosages effective for depression without suffering akathisia. For now, let us assume that it is the dopamine receptor partial agonism that is responsible for the improvement you experience with Abilify. Prior to bexpiprazole, this was the only psychotropic drug capable of doing this. Brexpiprazole represents the second. Brexpriprazole is 8 - 10 times more potent than Abilify per milligram. For depression, you may only need 0.5 - 1.0 mg/day. 4.0 mg/day is considered the maximum dosage for treating schizophrenia.
At 1.0 mg/day, the incidence of akathisia for brexpiprazole during clinical trials was 4.0%. Unfortunately, the statistics for Abilify do not include results for different dosages. For all dosages combined, it is 10 - 14%. Ask your doctor what his impressions are regarding brexpiprazole and akathisia. How many people has he tried it on? I don't think it would hurt too much for you to try it. You would know quickly whether or not it will help with depression or cause akathisia.
I am less than well with my current treatment, but better than nothing. Thanks for asking.
I recently switched from nortriptyline to desipramine to reduce weight gain. So far, I have lost 5 lbs in less than a week. That leaves only 55 lbs more to go. I don't feel quite as well, but I am only one week into treatment. I have been on this drug before, so I don't really expect magic.
I have bipolar I depression with drug-induced mania.
I am currently taking:
Parnate 60 mg/day
desipramine 150 mg/day
Lamictal 300 mg/day
lithium 300 mg/day
Abilify 10 mg/day
prazosin 30 mg/daySome unusual things to try include prazosin, N-acetylcysteine (NAC), minocycline, resveratrol, and ketamine (intranasal). Of course, there are the botanicals (herbal medicines) for which I am not familiar enough to comment on. I think curcumin is currently receiving quite a a bit of attention. Studies on rats look good. Studies on people? I don't know.
http://www.psychiatrist.com/jcp/article/Pages/2014/v75n10/v75n1011.aspx
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1083714
URL: http://www.dr-bob.org/babble/20150929/msgs/1083745.html