Novel AD in phase 3 - K-opioid receptor antagonist

Posted by TriedEveryMedication on November 2, 2015, at 10:25:38

The pipeline for new ADs has been pretty bleak lately. This one seems completely different. Approval in 2016 if it passes phase III trials.
https://en.wikipedia.org/wiki/ALKS-5461
"ALKS-5461 is a combination of buprenorphine, a moderate partial agonist of the mu-opioid receptor (MOR) and antagonist/very weak partial agonist of the Kappa-opioid receptor (KOR), and samidorphan, a selective antagonist of the MOR. The combination of these two drugs results in what is functionally a selective blockade of KORs with minimal or negligible effects on the MOR."
P.s. - Bob - fix your charset on your server so it doesn't mangle Greek letters!

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Novel AD in phase 3 - K-opioid receptor antagonist TriedEveryMedication 11/2/15
Re: Novel AD in phase 3 - K-opioid receptor antagonist Lamdage22 11/3/15
Re: Novel AD in phase 3 - K-opioid receptor antagonist Horse 11/3/15
Re: Novel AD in phase 3 - K-opioid receptor antagonist linkadge 11/5/15
Re: Novel AD in phase 3 - K-opioid receptor antagonist SLS 11/13/15

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