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My meds and p450 liver metabolism (SLS and others)

Posted by Lamdage22 on November 11, 2015, at 13:19:16

Hey yáll..

I want to replace the Zyprexa with Cannabidiol and if possible also replace the Seroquel with Cannabidiol. If i can replace Zyprexa and Seroquel, i probably wouldnt need Metformin anymore either (it makes me loose hair).

Scott, you told me to research and i did.

Here is what i found out about the cytochrome p450 enzymes that metabolize my meds.

Seroquel: Cyp 3A4
Zyprexa: Cyp 1A2, to a lesser extent: Cyp 2D6
Nortriptyline: Cyp 2D6
Venlafaxin (complicated: see link): https://www.pharmgkb.org/pathway/PA166014758
Cannabidiol: Cyp 3A4, Cyp 2C19, Cyp 2B(x)??? (cyp 2b subfamily, not sure which enzyme!)
Metformin is not metabolized by the liver.

What does this mean for my treatment? Is it possible and advisable?

THX

schizo-affective, type depressive
Nortriptyline 50mg
Seroquel 700mg
Zyprexa 12.5mg
Effexor 37.5mg
Metformin 2000mg
Lithium orotate 360mg
Some Vitamin D

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poster:Lamdage22 thread:1083961
URL: http://www.dr-bob.org/babble/20150929/msgs/1083961.html