Posted by michaelroberts on November 29, 2015, at 11:00:48
In reply to Re: Gepirone is Back for Another Round » michaelroberts, posted by SLS on November 28, 2015, at 15:36:18
> > http://www.medpagetoday.com/Washington-Watch/Washington-Watch/54903
> >
> > "On Friday, the FDA's Psychopharmacologic Drugs Advisory Committee will review gepirone hydrochloride extended-release tablets for treating depression."
> >
> > Has anyone heard anything about this? It has been years since Gepirone has been up for review. I'm glad we may finally get a novel treatment for depression without the SSRI side effects.
> >
>
> Have you tried Brintellix (vortioxetine)? It is similar in effect to gepirone but with added serotonin 5-HT7 receptor antagonism. Of course, each molecule is different. I imagine there will be people who respond to gepirone who would not respond to Brintellix.
>
>
> - ScottThanks Scott. The issue with Brintellix is that it is also a serotonin reuptake inhibitor in addition to the 5-HT agonist effect It is the serotonin reuptake inhibition that seems to cause the side effects, just like the rest of the SSRIs. I was hoping that we would finally see something that didn't have all the side effects and wasn't another antidepressant that was also an SSRI.
Looking at recent journal articles on Gepirone, it looks like it has a much better side effect than any antidepressant for sexual dysfunction. It actually has a positive improvement over placebo on sexual dysfunction in both men and women. That is amazing. It strikes me as very odd that the FDA hasn't approved this one.
http://www.ncbi.nlm.nih.gov/pubmed/21324094
http://www.ncbi.nlm.nih.gov/pubmed/22240272
poster:michaelroberts
thread:1084249
URL: http://www.dr-bob.org/babble/20151119/msgs/1084273.html