Posted by SLS on February 2, 2016, at 8:06:55
In reply to Re: NSI-189 phosphate, posted by pleuraleffusion on February 1, 2016, at 16:21:15
Hi.
> No one seems to know how NSI-189 works.
That's rather inconvenient.
> The molecule is supposed to increase hippocampal neurogenesis, but this doesn't really indicate anything about the mechanism.
True.
> A google search turned up this article as the first result: http://www.brainprotips.com/nsi-189-mechanism-of-action/It's a good article despite its uncertainty over NSI-189 mechanisms.
> But I have no idea if it's reliable - not a neuroscientist. I'm skeptical of the idea that it blocks cortisol - isn't that what RU486 does? Ru486 is the morning after birth control pill.
RU-486 (mifepristone) is not the "morning after" pill. It is an abortifacient that helps to induce an abortion well after conception. It is combined with misoprostol when used for this purpose.
It is suggested that mifepristone works for psychotic depression by blocking glucocorticoid receptors in order to suppress the actions of cortisol. One of the problems with this is that it causes the adrenal glands to produce too much cortisol via a negative-feedback loop. This is hard on the adrenals and can ultimately lead to adrenal fatigue.
For psychotic depression, mifepristone is administered for 8 days only. Thereafter, the therapeutic effects persist.
* It is only the psychotic component of psychotic depression that is supposed to be ameliorated by mifepristone. Studies could not demonstrate a true antidepressant effect.
I tried mifepristone to see if it would help with bipolar depression without psychosis. It didn't. Instead, I felt strangely washed-out by the end of the week. I would not recommend mifepristone.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1085537
URL: http://www.dr-bob.org/babble/20160131/msgs/1085884.html