Posted by Larry Hoover on February 4, 2016, at 12:11:09
In reply to Re: Intranasal NRX-1074 or intravenous injection, posted by Lamdage22 on January 31, 2016, at 10:30:25
I admire your willingness to push the envelope, but I share Scott's concerns about your jump to 10 mg IV injection of this investigational drug.
The Phase 2 clinical trial includes doses of 1 and 5 mg, but you have selected the highest dose, 10 mg.
https://clinicaltrials.gov/ct2/show/study/NCT02067793?view=record
Moreover, and as Scott has cautioned, you can be sure that the clinical trial will use an IV drip, not a bolus injection.
If you have obtained 100 mg of this drug, you're not faced with an all-or-nothing opportunity.
I'd like you to consider titrating your dose based on your response. Why not begin with 1 or 2 mg?
And I'd very much like to recommend to you that you go IM with whatever dose it is that you have selected. Even with someone present, you are not going to be medically supervised, as you certainly would be if you were in a clinical trial.
If you don't control the risk factors, you may well discover that the risk factors control you.
Regards,
Lar
poster:Larry Hoover
thread:1085796
URL: http://www.dr-bob.org/babble/20160131/msgs/1085938.html