Posted by SLS on February 29, 2016, at 7:20:14
In reply to Parnate, posted by Bob on February 28, 2016, at 23:37:00
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> I was doing some reading on Parnate today and was surprised to learn that the drug has a half-life of a mere 2.5 hours. Is it recommended to dose this drug multiples times per day to compensate for this short half-life?
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> BobIt is recommended to take Parnate in divided doses. You can divide them by taking one dose in the morning and one in the early afternoon.
Parnate gets in quickly and binds to MAO permanently. Any excess is metabolized quickly, but the number of inactivated MAO enzymes remains the same. The necessity to dose on a regular basis is to offset the synthesis of new MAO.
Several people on Psycho-Babble take all of their Parnate dosage once in the morning. If orthostatic hypotension becomes a problem, I would consider taking Parnate 3 times a day, with your final dose to be taken at 3:00 PM if insomnia is a problem. Blood pressure usually ebbs at 4:00 PM. I used to have a cup of coffee at this time to reduce hypotension. However, the longer I took Parnate, the less hypotension was a problem.
What is your current treatment regime, if you don't mind my asking?
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1086592
URL: http://www.dr-bob.org/babble/20160131/msgs/1086601.html