Posted by linkadge on April 8, 2016, at 17:39:43
In reply to Re: replace zyprexa with what? » linkadge, posted by J Kelly on April 8, 2016, at 12:53:25
For an individual responding to an atypical (for depression augmentation), it is necessary to realize that atypical antipsychotics non-selectively block both serotonin and dopamine receptors. It is thought that the serotonin (not dopamine) blockade is responsible for the antidepressant qualities of atypical antipsychotics. Mirtazapine blocks the same serotonin receptors (5-ht2a/c) but does not block dopamine receptors. Hence, it may not induce as much anhedonia / motor side effects.
Mirtazapine can cause weight gain (and improve sleep) like olanzapine, but *may* produce less apathy / anhedonia as a side effect.
It is a stronger antihistamine than olanzapine, so it could cause more increase in appetite.
However, I never gained much weight (unfortunately) on either olanzapine nor mirtazapine, although mirtazapine was better for my mood.
Linkadge
poster:linkadge
thread:1087856
URL: http://www.dr-bob.org/babble/20160331/msgs/1087985.html