Posted by Tomatheus on April 19, 2016, at 23:17:29
In reply to Escatilopram with Nortriptylene and Valdoxan, posted by JohnWatford on April 19, 2016, at 17:36:21
Hello, and welcome to Psycho Babble. My opinion on your situation is that giving the two medications that you're currently taking some time to determine what their effects will be after a few more weeks or so would make the most sense, as long as you're not in a crisis, and as long as you're not experiencing any adverse effects that might prompt your doctor to make some changes to your medication regimen. I definitely think that it would be best to evaluate how taking nortriptyline along with Lexapro will affect you a little further down the line before putting too much thought into adding a third medication into the mix.
As far as my thoughts on Valdoxan are concerned, I tend to think that the medication would likely be more beneficial for individuals who have trouble staying asleep and might also have problems with waking up too early, as compared to individuals who sleep excessively and tend to have a lot of difficulty waking and getting out of bed. One of the things that Valdoxan does is basically mimic the effects of the hormone melatonin at two of the receptor sites that the hormone binds to, and melatonin is secreted when we're exposed to darkness and is thought to help regulate sleep. Valdoxan also has pharmacological actions that don't involve the melatonin system, such as blocking one of the serotonin receptors, the 5HT2C receptor. I haven't taken Valdoxan, but I have taken melatonin supplements, and those seemed to worsen my depressive symptoms. I should note that I sleep excessively and have a difficult time waking up and getting out of bed due to extreme morning fatigue when I'm not responding well to treatment, and melatonin basically made these problems worse.
What does your sleep look like, particularly when you're not receiving or responding to treatment?
Tomatheus
"Maybe someday
We'll figure all this out
We'll put an end to all our doubt
Try to find a way to just feel better now"- Rob Thomas
poster:Tomatheus
thread:1088305
URL: http://www.dr-bob.org/babble/20160331/msgs/1088313.html