Posted by SLS on October 27, 2016, at 6:50:34
In reply to Lime 'n' Luvox, posted by Prefect on October 26, 2016, at 20:05:55
> I've read grapefruit juice can affect the absorption of Luvox. But what about limes and lemons, which I consume almost everyday in my salad/sparkling water? I take 100 mg of Luvox/day
It's not absorption that is acting on Luvox here. It is a reduction of metabolism in the liver that occurs after absorption that creates the higher levels of Luvox. After absorption from the digestive tract, Luvox is carried in the blood to the liver. In the liver, the furanocoumarin contained in grapefruits slows things down for Luvox metabolism by inhibiting an enzyme know as CYP3A4. Sweet oranges and lemons don't have appreciable amounts of furanocoumarins in them, and would not react with Luvox. In general, limes have low levels of furanocoumarindo, but I don't know for sure to what extent it affects Luvox levels.
Sorry I couldn't have been more help.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1092775
URL: http://www.dr-bob.org/babble/20160928/msgs/1092779.html