Posted by SLS on November 28, 2017, at 21:28:35
In reply to Re: Everything is good, except for depression, posted by linkadge on November 28, 2017, at 19:52:01
> Hey SLS,
>
> desipramine seems to have a lower cardiac safety index than the other TCAs. I (personally) would be cautious about using it with lithium. I have been getting some weird cardiac effects from lithium and nortriptyline.
>
> Linkadge
Bundle-branch block?When I first started taking desipramine, I experienced rapid heartbeat and palpitations. There was also a sort of "edginess" that disappeared over time. After a few weeks, palpitations disappeared completely, but rapid heartbeat only partially mitigated. I don't think there is anything wrong with having a moderately elevated heart rate, though. I've been on TCAs for over 30 years. I'll let you know after my first stress-test. My EKGs are normal. All I can say is that combining Parnate + desipramine sure packed a wallop the first time they were used together in me. My autonomic nervous system felt like it was being fried. Good stuff. I reached remission within a few months (1987). To keep a long story from becoming longer, I never responded to that treatment again.
It is a matter of risk/cost/benefit.
I hope you are doing reasonably well. It is relative, I guess. When someone asks me how I am doing, I usually answer that I could be doing worse - knowing that I could be doing a hell of a lot better.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1096046
URL: http://www.dr-bob.org/babble/20161215/msgs/1096088.html