Posted by ed_uk2010 on March 3, 2018, at 16:01:03
In reply to Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by farshad on March 3, 2018, at 4:35:16
>according to the Modafinil own page it says at 300mg Modafinil inhibits 50% dopamine transporters, thats not weak.
It could be weak according to the clinical effects exerted; even though 50% 'sounds' like a decent percentage, it may not be.
If you look at SSRIs for example, a dose which blocks 50% of transporters is not clinically effective. The dosages used in practice block a much higher percentage of transporters.
The same sort of situation applies to antipsychotics when used in psychosis. Blocking 50% of dopamine D2 sites does not appear useful. Therapeutic doses of most antipsychotics block a much higher percentage.
poster:ed_uk2010
thread:1097137
URL: http://www.dr-bob.org/babble/20180212/msgs/1097153.html