Posted by farshad on March 19, 2018, at 14:16:15
In reply to Re: How can I block Cortisol?, posted by farshad on March 19, 2018, at 14:13:05
> has anyone seen this study ? its from 1998 . I think they are suggesting there could be CRF1 mutations but unrelated to cushings disease>
>
> I quote from the study ...No mutations affecting the CRF1-R protein have been found in all tumors analyzed. However, we found a significant overexpression of the CRF1-R messenger RNA in ACTH-secreting pituitary adenomas vs. inactive adenomas and normal pituitaries. We conclude that mutations of the CRF1-R are unlikely to be involved in Cushing's disease. We suggest that the overexpression of the CRF1-R messenger RNA may be related to a disturbed receptor regulation in ACTH-secreting pituitary adenomas...
>
> https://www.ncbi.nlm.nih.gov/pubmed/9745449
>
> English is my 3rd language so maybe someone can explain this that understands it better_I found 2 possible mutations that I have related to ACTH>
PDE8B https://www.selfdecode.com/gene/pde8b/#advanced-summary
ACE (Angiotensin I converting enzyme) https://www.selfdecode.com/gene/ace/
poster:farshad
thread:1097352
URL: http://www.dr-bob.org/babble/20180212/msgs/1097508.html