Posted by SLS on March 21, 2018, at 11:09:55
In reply to Re: Remeron Brain Zaps?!, posted by Prefect on March 20, 2018, at 19:51:15
You might want to try prazosin, a NE-1a/b/d receptor antagonist. It treats PTSD and the depression and anxiety that accompany it. I am having success with it at 20 mg/day. You don't necessarily need to have classic PTSD in order for prazosin to work. A history of childhood adversity (chronic abuse and neglect) can produce C-PTSD (complex PTSD).
Alternatively, you can try propranalol, a NE beta antagonist, to reduce sympathetic activation. I don't know for certain that you can combine prazosin and propranalol together. Hypotension would be an issue. I'm guessing yes, though. Coreg (carvedilol) is a dual-action drug that combines NE beta blockade and NE alpha-1a blockade. It is used often for heart failure. If you are going to try prazosin, you must initiate treatment with a single 1 mg dose immediately before going to bed, or else dizziness and syncope can result. You can then begin to titrate the dosage upwards. You can take 2-3 mg on day 2 and go from there. Be sure to dose 2-3 times a day. Prazosin has a short half life. The only side effect I experience is a diminution of sex-drive. It is a pretty big compromise to make, but I don't have a better choice at the moment.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1097491
URL: http://www.dr-bob.org/babble/20180212/msgs/1097546.html