Posted by farshad on April 2, 2018, at 1:22:47
In reply to Re: How are you doing? » farshad, posted by ed_uk2010 on April 1, 2018, at 17:40:47
> Hi Farshad,
>
> There are a few different types of Cushing Syndrome. All types cause a large elevation of cortisol. The reason for cortisol being elevated differs between the different types.
>
> >People with cushings have a tumor in the pituatary which releases constant cortisol and cortisol is a non peptide hormone and the effects would be very different wouldnt it? . isnt there a difference?
>
> One cause of Cushing's is a tumour in the pituitary. It releases ACTH, not cortisol. The large amounts of ACTH cause the adrenal glands to produce large amounts of cortisol. The highly elevated cortisol levels then cause the symptoms.
>
> >I have a tumor in the paraventricular nucleus which releases CRH and CRH is a Peptide hormone
>
> Tumours releasing CRH are a very rare cause of Cushing Syndrome. The high CRH causes the pituitary to produce large amounts of ACTH. The ACTH causes the adrenal glands to produce large amounts of cortisol. So, the overall effect of CRH-producing tumours is Cushing Syndrome (from very high cortisol).
>Can you tell me about the other 3?
I think a tumor in the nucleus would be different. Becuase it has to go like this CRH > ACTH .. So in between the two cortisol can inhibit ACTH if it gets too much. But if the tumor is in the pituatary it will just release ACTH directly doesent go trough other so theres no way your body can inhibit it.
CRH on its own work in different way than cortisol and ACTH I think. There are actually CRH receptors in the Amygdala and other parts of the brain. But there are no ACTH receptors in the brain as far as I know they are in the thyroid or adrenals one of them.
CRH is the only cortisol type in the brain.check out this picture http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/adrenal/feedback.gif
So a tumor in the CRH wouldnt mean high cortisol it would just mean constant CRH release which is a peptide not a hormone so it doesent have direct effect on the body like regular cortisol. It can cause high levels of cortisol yeah but not cushings high. I belive I do have high cortisol but not like people with cushings and I do have high ACTH also but since there is a loop that your body has its own way of combatiing it so my level arent of the chart.
Its just the constant CRH release that ruins my brain and gives me this anxiety which in turn breaks down my body.
poster:farshad
thread:1097352
URL: http://www.dr-bob.org/babble/20180331/msgs/1097913.html