Posted by Hordak on August 22, 2018, at 15:59:44
In reply to Re: Experiences with Clomipramine ('Anafranil')?, posted by linkadge on August 22, 2018, at 7:53:59
> It's difficult to say whether agitation will be better or worse on clomipramine. I would say that apathy / anhedonia (for me) were much better on clomipramine than sertraline.
>
> Clomipramine was better for sleep. The noradrenergic effects can give you more energy, but for some, may increase agitation.
>
> You'd have to try it to know for sure. However, I would say it's feel is only remotely similar to an SSRI. There are many other targets which give it a very distinctive effect.
>
>
> Linkadge
>My first idea was to augment Sertraline with Nortriptyline, but those f*ck*rs have withdrawn it from the German Market.
Clomipramine seems like a multi-talent: strong SRI, strong NRI, moderate antihistamine, 5HT2-antagonist, antagonist of the alpha1-adrenergic-recpetors, strong neuro-regenerative features, all rolled into one pill.
SSRIs alone make me indifferent and apathetic. I need something in addition to boost my "motivation" & "hedonia"...
poster:Hordak
thread:1100500
URL: http://www.dr-bob.org/babble/20180728/msgs/1100532.html