Posted by pedr on January 16, 2019, at 12:02:45
In reply to Stimulant switch., posted by MightyKondrian on December 28, 2018, at 13:16:47
> I also been on Phenelzine now for 2 yrs. Half that time on 120mg. I asked surely its pointless? I've felt it do nothing since I restarted it. He said it will be doing something. I mean, do it's actions stay the same long term whether it poops out or not? Does it still inhibit MAO to the same degree whether you feel it or not, or poops out? Can MAO build a tolerance to Nardil's inhibition (forget GABA for now)? If not, and inhibition is its main function then what else is going on? The mystery of psychopharmacology. Nobody really knows. A jigsaw with missing pieces.
So I have 20+ years of TRD and have tried Nardil twice and Parnate once. The first time I tried Nardil, I was blessed to have a progressive PDoc who also prescribed stimulants alongside it. It was by FAR the best treatment I've ever been on.
Sadly that ended and the other two attempts simply didn't work. On Parnate I got insomnia and significantly more depressed. On Nardil attempt #2 it simply did nothing. Sure the "texture" or facets of my depression changed but my overall mood was still in the toilet.
So I say yes, it's a waste of time. MAOI's don't work for everyone by a long measure. Your PDoc needs a slap.
I'm titrating up on Trintellix and Rexulti at the moment after doing a genesight DNA test that helped identify meds that simply won't work for me (which include most of the other SSRI's).
FWIW I've done Ketamine, ECT, dTMS (42 sessions!) and all did zip.
HTH, Pete
I love the smell of Abilify in the morning. The smell, you know that chemical smell. Smells like victory. Some day this war's gonna end...
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Atypical Depression, OCD, IBS-C, GERD since '96
poster:pedr
thread:1102630
URL: http://www.dr-bob.org/babble/20181024/msgs/1102815.html