Posted by linkadge on February 14, 2019, at 15:19:42
In reply to Does anyone know how to activate Trk-B?, posted by SLS on February 9, 2019, at 13:16:56
In the case of amitriptyline, it directly activates the trk-b receptors (i.e. directly mimicking BDNF). I don't think other antidepressants directly activate trkb (i.e not trkb agonists), but some directly activate the sigma receptors (which I think can interact or synergise with TRK-B receptors). I know imipramine (somehow) activates the pathway without directly binding to trk-b. A combination of fluvoxamine (sigma agonist) and amitriptyline (TRK-B) agonist, could be a synergistic 'neurotrophic' combination.
I'm not sure of the mechanism of how other antidepressants activate TRK-B. It may be related to epigenetics (i.e controlling receptor sensitivity) or perhaps some alternative binding site (sorry, I'm only an armchair biologist).
rTMS activates the BDNF pathways (even outside the brain) suggesting a non-neurotransmitter mechanism for activation.
This flavonoid "7,8-dihydroxyflavone" can be bought as a supplement and supposedly acts as a trkb agonist. GSK3 inhibitors supposedly activate TRKB without BDNF.
Linkadge
poster:linkadge
thread:1103177
URL: http://www.dr-bob.org/babble/20190206/msgs/1103233.html