Posted by SLS on February 17, 2019, at 10:49:59
In reply to Intolerant to many medications...opinons?, posted by plenair on December 1, 2018, at 9:16:21
> Hi,
>
> I am sensitive to most medications. I have anxiety and ocd. I haven't had relief with many drugs including but not limited to benzos,beta-blockers, alpha blockers, gabapentin and SSRIs. These drugs have all caused many side effects, some of which I can live with. No drug has had good efficacy for my problems. However, I cannot tolerate certain side effects. SSRI's cause certain intolerable side effects including urinary hesitancy, bladder pain and ringing in my ears. I have been reluctant to try SNRIs, TCAs or AAPs due to my extreme sensitivity to medications, which are acknowledged by my doctors.
>
> Can any serotonergic agent help? Any opinions on what a very sensitive person can take? Thanks.I would be interested to know how you reacted to Prozac (fluoxetine) and at what dosage?
Paxil (paroxetine)?
Calling Lyrica (pregabalin) as being little more than a stronger Neurontin (gabapentin) when treating anxiety disorders (of which OCD is one) might neglect pharmacologic effects other than blocking the alpha-2-delta subunit of the calcium channel. It would be great to know if there are any. Having taken both drugs, I found that Lyrica initially produced an effect that reminded me of alcohol intoxication. Neurontin did not do this. I don't know if this proves anything, but that was my experience.
Clomipramine (Anafranil) is a strong anticholinergic. Many people can't tolerate it, but it might be worthwhile to test the drug to see how it affects you. For now, it is usually considered to be the most powerful anti-obsessionals available. You can always stop taking it if you are unhappy with it. In the worst of cases, some doctors combine clomipramine with a SSRI.
Was there ever a time when you were not sensitive to medication? What do you experience as sensitivity? What treatment has worked best so far? Why did you discontinue it?
Both Lyrica and Neurontin produced in me severe cognitive impairments and a scary, unrelenting brain fog that lasted for many weeks after I discontinued the offending drug.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1102225
URL: http://www.dr-bob.org/babble/20190206/msgs/1103273.html