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Re: Annoying lip spasm, olanzapine?

Posted by Christ_empowered on April 3, 2019, at 4:06:29

In reply to Re: Annoying lip spasm, olanzapine?, posted by Lamdage22 on April 3, 2019, at 0:24:26

hi. olanzapine -is- still a neuroleptic...which means there's an EPS risk (that's more of an acute reaction...muscle twitches, that kinda thing) and TD (tardive dyskinesia...facial tics, usually...with atypicals, there's a good chance they'll stop, -if- the offending drug is removed) risk.

the old drugs carried an annual TD risk of about 5%. The newer drugs...the best estimate I've heard is, pooled together, about 3.9%. so...the 'atypicals' are somewhat better than taking, say, Prolixin or Haldol...

but not by a huge, massive %. :-(

Seroquel sometimes helps, mainly because its lower potency, and lower potency neuroleptics usually have a lower TD risk than higher potency drugs. Haldol has a higher risk than, say, Thorazine...

and dosage plays a role. 400mgs/Thorazine may not be the greatest thing ever for mood (dysphoria, etc.), but the TD risk may be about the same as, say, 15-20mgs/olanzapine. One reason the 'atypicals' looked so great on paper is that a lot of the early studies (especially risperidone) were done vs excessively high doses of Haldol. I don't know if you've ever experienced the joys of vitamin H, but...

it doesn't take much to beat Haldol, in terms of patient satisfaction and adverse effects.

age (above 40-45, I think), gender (women more than men), mood disorder (moody people=higher risk), and early onset EPS are all risk factors. The 'severely manic depressive' seem especially prone to severe TD. :-(

if low dose olanzapine is doing this, I'd seriously talk to a prescriber about -not- taking a neuroleptic. maybe...buspar (buspirone) ? just a random suggestion.

sorry about this.


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