Posted by linkadge on April 14, 2019, at 18:31:29
In reply to Reverse Steady State Calculation(???), posted by Schlepo on April 14, 2019, at 14:38:12
It should be fairly quick (days really). There would be some individual variation based on liver enzyme status. I know for nortriptyline, there are fast metabolizers and slow metabolizers. Even so, I can't see it taking more than a week.
Now that being said, just because the body reaches a lower steady state (blood level) in that time, doesn't mean the brain (necessarily) fully adjusts in that time. There are other factors like disease severity, receptor sensitivity etc. that will affect how quickly (or long) it takes for an individual to adjust.
Also, I think that the drug can 'build up' to some extent, in the brain. So, even if the blood levels drop, there may be a higher amount in the brain, for some time (no idea how long).
Furthermore, the downstream actions of the drug could take longer to reverse themselves. I.e. the drug immediately affects norepinephrine, but that activation can lead to downstream effects, perhaps epigenetic, that could take some time to revert.
Linkadge
poster:linkadge
thread:1103970
URL: http://www.dr-bob.org/babble/20190206/msgs/1103974.html