Posted by TH on April 28, 2019, at 17:50:27
In reply to Re: Ketamine nasal spray, posted by Roslynn on April 28, 2019, at 16:32:25
> Does anyone know how the generic compounded version differs from Spravato in efficacy or active ingrediants?
We haven't heard exactly what was in the generic version from above, but as for "Spravato":
"Each device delivers two sprays with a total of 32.3 mg of esketamine hydrochloride (equivalent to 28 mg of esketamine) in 0.2 mL of a clear, colorless aqueous solution with a pH of 4.5. The inactive ingredients are citric acid monohydrate, edetate disodium, sodium hydroxide, and water for injection."
The edetate disodium seems to be added with the aim of preventing sinus infections, but maybe someone else will know better. I suppose the citric acid is added to maintain the low PH, but whether this is as a preservative or helps with absorption, I couldn't say.
poster:TH
thread:1104157
URL: http://www.dr-bob.org/babble/20190206/msgs/1104204.html