Posted by mtom on May 29, 2019, at 16:35:02
In reply to Re: Mirtazapine/Remeron recent experience, SE's, etc? » mtom, posted by TH on May 29, 2019, at 15:23:52
> I haven't personally taken it, but I believe its real world effectiveness is much lower than its clinical trials suggested.
From the research I've done (and I've done a lot), this seems to be the case with most if not all antidepressants. That is, the clinical trials done by the Pharma companies to gain approval do not seem to reflect post-marketing follow-ups done by others. The initial trials also seem to generally show lower percentages of adverse effects than are later reported (although not many post-marketing studies are done for these, and most are small - they don't have the funding the Pharma companies do to perform large studies).
In studies I have found where they compared head to head with placebo, it appears the antidepressant response rate often isn't all that much higher than the placebo response rate on average....
Still, interested in hearing from others as there are a few studies showing Mirtazapine is more effective than most others. However, some of these are review studies, looking at many small studies with varying degrees of bias, possible confounding factors, varying rates of compliance and drop-outs, etc. Difficult to find really "good" data.
poster:mtom
thread:1104640
URL: http://www.dr-bob.org/babble/20190513/msgs/1104643.html