Posted by linkadge on July 31, 2019, at 15:25:03
In reply to sigma 1 receptor and Luvox, posted by joe f on July 31, 2019, at 8:36:18
Fluvoxamine activates it most potently followed by citalopram and fluoxetine. It is involved in calcium homeostasis, neurogenesis and neuroprotection.
Sigma agonists, on their own, exhibit antidepressant and anti-anxiety effects. They also have the ability to improve cognition. Fluvoxamine, for instance, can reverse the cognitive impairment from a variety of drugs (like anticholinergics) while other antidepressants don't seem to do this.
The natural hormone DHEA is a sigma agonist, whereas progesterone is a sigma antagonist.
Linkadge
poster:linkadge
thread:1105535
URL: http://www.dr-bob.org/babble/20190728/msgs/1105539.html