Posted by linkadge on December 31, 2019, at 18:07:46
A new study reveals that choline itself is a sigma-1r agonist. Sigma agonists are known to improve cognition. Some of the alzheimers drugs (like ariciept) increase acetylcholine by slowing its breakdown AND act as sigma-1r agonists.
https://www.sciencedaily.com/releases/2019/01/190114113529.htm
However, a new finding suggests that choline itself is a sigma agonist. This means that it has the potential to improve cognition in two ways (by activating acetylcholine receptors and sigma receptors. Interestingly, parenteral choline intake is inversely associated with risk of schizophrenia as are sigma agonists like fluvoxamine. Perhaps the sigma receptor is a common target.
Choline, for some, can cause depression. However, personally, I find it can ground me (during certain states).
Linkadge
poster:linkadge
thread:1107580
URL: http://www.dr-bob.org/babble/20191019/msgs/1107580.html