Posted by undopaminergic on January 10, 2020, at 11:03:50
In reply to Re: Dextromethorphan/Bupropion for MDD soon..... » PeterMartin, posted by pedr on January 10, 2020, at 9:31:01
> Would tablets be worth a shot do you think?
Yes, absolutely.
I had an antidepressive response to a dextromethorphan (DXM) pill once. I figured it might be the serotonergic action, because the effect came so soon(*) and the dose was so low.
(*) the NMDA-antagonism comes largely from metabolism to dextrorphan; hence it takes some time till the onset.
DXM also binds to sigma-receptors. I'm not sure whether it is an agonist or antagonist.
-undopaminergic
poster:undopaminergic
thread:1107271
URL: http://www.dr-bob.org/babble/20200104/msgs/1107804.html