> Yeah, clonidine can be used off label for anxiety and sometimes insomnia. You might check your blood pressure on the desipramine. If it's on the high side, this might be more of a case for something like clonidine.
>
> Clonidine activates a receptor (alpha-2) that puts the break on norepinephrine release. It is often used in combination with stimulants (for ADHD) to enhance the effect and offset some of the anxiety / side effects.
>
> Linkadge
For many people, clonidine produces profound depression. I guess that's not surprising given its action on NE alpha-2 receptors. My grandmother, who had never experienced depression before, became very depressed immediately upon starting clonidine. It resolved upon discontinuation.
- Scott
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this signature | Show by default | Change to hide (next time)Some see things as they are and ask why.
I dream of things that never were and ask why not.
The only thing necessary for the triumph of evil is that good men do nothing.