Posted by undopaminergic on June 20, 2020, at 5:06:18
In reply to Re: Atomoxetine helping - fingers crossed » undopaminergic, posted by SLS on June 19, 2020, at 19:55:41
> > Modafinil is supposedly a central alpha1B-adrenoceptor *agonist*, hence purportedly its "eugeroic" effects, as separate from its stimulant action.
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> Modafinil has always been a bit of an enigma. First, it was dopamine reuptake inhibition. Then, it was orexin activation. It turns out that orexin is more important for alertness / cognition than it is for wakefullness.
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> "Modafinil-induced wakefulness can be attenuated by the alpha-1 adrenergic antagonist, prazosin, which led to the initial conclusion that modafinil stimulates the central alpha-1 adrenergic system. However, in vitro assay systems responsive to alpha-adrenergic stimulation have not shown that modafinil is a direct or indirect alpha-1 adrenergic agonist."
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> https://www.wellrx.com/modafinil/monographs/
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> - ScottThe dopamine transporter binding of modafinil has been ascertained, including proven essential for its effects. I don't know about other actions. It would be ironic if the atypical stimulant profile of modafinil were due to the *lack* of noradrenergic actions, ie. selectivity for dopamine.
-undopaminergic
poster:undopaminergic
thread:1110783
URL: http://www.dr-bob.org/babble/20200511/msgs/1110870.html