Posted by linkadge on June 24, 2020, at 7:35:54
In reply to Re: How does Lumateperone compare to antidepressants?, posted by undopaminergic on June 23, 2020, at 21:32:29
From what I understand, over-activation of the 5-ht1a receptor is part of the process mediating serotonin syndrome (both 5-ht1a and 5-ht2a mediate different aspects of serotonin syndrome). When you block one serotonin receptor, this leaves more serotonin to activate other receptors (i.e. 5-ht1a).
Again, I said the risk was very very low, but there have been case reports of serotonin syndrome when adding atypical antipsychotics to SSRIs.
For example:
https://pubmed.ncbi.nlm.nih.gov/12639169/
(although there is some overlap between the symptoms of serotonin syndrome and neuroleptic malignant syndrome).
Linkadge
poster:linkadge
thread:1110979
URL: http://www.dr-bob.org/babble/20200511/msgs/1111004.html