Introduction to nicotinic receptors and nicotine

Posted by undopaminergic on September 28, 2021, at 14:23:48

I just finished reading this article, which is a good introductory review of nicotinic acetylcholine receptors and nicotine addiction:
https://sci-hub.se/https://doi.org/10.1016/j.neuropharm.2020.108256
It claims nicotine has a half-life of 20 hours in humans. That doesn't sound right to me. Wikipedia reports a half-life of only 1-2 hours, although it mentions a metabolite, cotinine, with a half-life of 20 hours.
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Introduction to nicotinic receptors and nicotine undopaminergic 9/28/21
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