Posted by linkadge on February 20, 2022, at 17:38:39
In reply to Re: Anyone try CBD?, posted by undopaminergic on February 20, 2022, at 12:52:57
CBD is pleiotropic (multiple mechanisms) and the mechanism is not completely understood. However some of the known mechanisms include:
-5-ht1a agonism (moderate)
-d2 presynaptic agonist (like abilify)
-gaba-a positive modulator
-indirect sodium channel antagonist
-TRVP-1 agonist (anticonvulsant/analgesic effects)
-inhibits anandamide metabolism by inhibiting fatty acid binding proteins
- not a direct cb1/cb2 agonist, but may indirectly increase receptor activity
-anti-inflammatory effectI use CBD daily, and get a good effect from 20-50mg a day. For me, it completely replaced ativan, and has virtually cured my chronic insomnia, in conjunction with mirtazapine. I purchase dried CBD rich herb, decarboxylate (cook) it using the Ardent decarboxylator, then I grind it measure it out, and then put it in my mouth. Then, I add olive oil (more on this below) and then chew the mixture to help extract / release the CBD. The effects are felt within about an hour. Supposedly, CBD has lowish oral bioavailability. The bioavailability can allegedly be enhanced with piperdine (form black pepper). I add black pepper (which also has cannabinomemetic properties) liberally to my foods throughout the day.
You need to make sure the product is from a reputable source, and I would encourage going right back to the dry herb. Some analysis of various OTC CBD oils has found significant inconsistency in potency as well as THC content.
Olive oil contains oleic acid, which is converted into oleamide. Oleamide (interestingly) has many mechanisms similar to CBD, namely:
-5-ht1a agonism
-Sodium channel inhibition
-d2 presynaptic agonism
-CB1 / CB2 agonismPersonally, if you're on high dose neuroleptics, I wouldn't try replacing them with CBD (unless you can get that synthetic CBD pill). That being said, I would say that 40 mg of CBD would have the sedative qualities of 25-50mg of seroquel. You could probably reduce the dose of your neuroleptic to some extent, but again, you'd need to be confident in the quality of the product you're getting.
If you were in Canada, you're always welcome to stop by for a sample from my system.
Linkadge
poster:linkadge
thread:1118679
URL: http://www.dr-bob.org/babble/20220128/msgs/1118695.html