Posted by Hugh on May 16, 2022, at 11:27:53
Researchers from the Girona Biomedical Research Institute (IDIBGI) and Pompeu Fabra University (UPF) in Barcelona, Spain, have identified the role of proline, an amino acid, in humans, mice and flies suffering depression. The results, published in the scientific journal Cell Metabolism, also associate the consumption of a proline-rich diet with a greater tendency to develop depression.
To reach these conclusions, the type and number of amino acids in the diet of the participants was analyzed. Participants also completed a questionnaire to measure their depressive mood. "We were surprised that what was most associated with depression, evaluated through this questionnaire, was the consumption of proline," says Dr. Fernández-Real, of the IDIBGI, and also head of the Endocrinology Section at Hospital Dr. Josep Trueta in Girona and director of the Department of Medical Sciences at the University of Girona. Confirming this, when plasma metabolomics were evaluated, the concentration of proline emerged as one of the metabolites most associated with indicators of depression.
But not everyone who had a high intake of proline referred in the questionnaire to being more depressed. When studying these people's intestinal microbiota, a relationship was also observed between depression and bacteria, as well as between depression and bacterial genes associated with proline metabolism. Thus, it was observed that circulating proline levels depended on the microbiota. "The microbiota of patients with high proline consumption but low plasma levels of proline was similar to the microbiota associated with low levels of depression and was enriched in bacterial genes involved in the transport and metabolism of proline," states Dr. Mayneris-Perxachs, a Miguel Servet researcher at the IDIBGI.
Complete article:
https://medicalxpress.com/news/2022-05-relationship-amino-acid-diet-depression.html
This study found that L. plantarum, a high GABA producer, protects against depression by decreasing plasma levels of proline:
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00128-0
Swanson brand L. plantarum probiotic:
https://www.swansonvitamins.com/p/swanson-probiotics-l-plantarum-inner-bowel-support-30-veg-drcaps
poster:Hugh
thread:1119703
URL: http://www.dr-bob.org/babble/20220128/msgs/1119703.html