Posted by undopaminergic on June 7, 2022, at 7:47:04
In reply to Re: Oral deprenyl vs bupropion? - More, posted by SLS on June 7, 2022, at 7:38:44
> I forgot to mention that taking L-deprenyl / selegiline orally is not terribly effective. I tried sit many years ago. I don't remember the pharmacological reasons for this, but I believe oral administration produces far less circulating selegiline. I think it might be broken down in the gut.
>The first-pass metabolism in the liver converts much of it to l-methamphetamine, l-amphetamine, and desmethylselegiline, but these metabolites are also responsible for some of the pharmacological effects of selegiline. I think the initial mood boost I got from it was due to the amphetamines. Research has revealed that a lot of the neuroprotective properties of selegiline are due to desmethylselegiline, which is also a MAO-B inhibitor.
-undopaminergic
poster:undopaminergic
thread:1119824
URL: http://www.dr-bob.org/babble/20220530/msgs/1119852.html