Posted by linkadge on July 25, 2022, at 10:09:50
In reply to Re: Amur Corktree arrived » linkadge, posted by Jay2112 on July 24, 2022, at 23:35:02
A recent theory has to do with G proteins. It's technical, and well above my pay grade but a brief summary....
A fairly recent study has suggested that virtually all antidepressants have been shown to push g proteins out of lipid rafts, where they are more likely to activate adenylyl cyclase. They do this in a serotonin independent manner. With slow acting antidepressants, this process takes about 2-4 weeks (mirroring the lag time for antidepressant response). Interestingly, rapid acting antidepressants like ketamine, achieve this effect within a single dose. Depressed patients have been shown to have a higher proportion of their g proteins located inside lipid rafts.
They can genetically engineer mice to have virtually no serotonin transporters. Yet, the mice still have a behavioural response to SSRIs comparable in magnitude to 'normal' mice.
https://neurosciencenews.com/ketamine-lasting-depression-9423/
Linkadge
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thread:1120116
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