Posted by SLS on July 28, 2022, at 16:08:12
In reply to Re: Does lack of motivation from Pristiq ever go away?, posted by linkadge on July 27, 2022, at 17:23:26
> Hi there,
>
> I don't have an answer for you, but am interested in any responses. Have you taken venlafaxine? Can you compare the motivational side effects between the two?
>
> I am seeing my doctor next week, and am (loosely) contemplating a switch from venlafaxine to desvenlafaxine.
>
> Linkadge
What is the rationale for making the switch?My guess is that Pristiq might be smoother than Effexor. Venlafaxine has been more helpful to me than desvenlafaxine. Coming off of Effexor was the decision made when we moved on to Nardil.
A friend of mine takes a combination of Wellbutrin + Pristiq. She described the Wellbutrin as helping with mental energy, and the Pristiq as giving her the "wannadoos". She had not taken Effexor previously, so I can't report a comparison with her. However, she has been in 100% remission for 13 years. She was somewhere between being dysphoric to moderately depressed. Parnate had been the only drug she responded to, although moderately at best.
It is possible that your intolerance to therapeutic dosages of venlafaxine is produced by the parent compound, and not the metabolite. They do feel different to me. Effexor gave me a kind of uncomfortable mental energy that Pristiq did not. I don't think I took more than 100 mg/day of Pristiq whereas I need 300 mg/day of Effexor to produce an improvement. 225 mg/day is insufficient.
Effexor = venlafaxine + desvenlafaxine (an active metabolite)
Pristiq = desvenlafaxineWhat is your best guess as to what Effexor does that Pristiq does not.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1120152
URL: http://www.dr-bob.org/babble/20220530/msgs/1120160.html