Posted by SLS on January 1, 2023, at 20:11:51
In reply to Lithium effects on hippocampal glutamate, posted by undopaminergic on January 1, 2023, at 17:37:19
> I just read this study:
> https://pubmed.ncbi.nlm.nih.gov/25522399/
> Title: "Bimodal effect of lithium plasma levels on hippocampal glutamate concentrations in bipolar II depression: a pilot study".
> The full article is available.
>
> My interpretation is that lower plasma lithium concentrations (< 0.50 mmol/L) are associated with a reduction of glutamate levels in the hippocampus, while higher lithium concentrations (>= 0.50 mmol/L) are associated with an increase. I would not have expected this.
>
> Note that the lithium doses were individualised, and that the changes in glutamate levels were not correlated with the changes in depressive severity. Apparently, some people feel better with a reduction in hippocampal glutamate and others with an increase. This is hardly surprising.
>
> -undopaminergic
>Yup.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1121444
URL: http://www.dr-bob.org/babble/20220917/msgs/1121453.html