Posted by McPac on September 5, 2003, at 12:03:45
In reply to Larry Hoover « Larry Hoover, posted by McPac on September 5, 2003, at 11:57:22
Lar, here is the abstract that Ame sent me. He said that Remeron was having a drastic influence on the efficacy of my SJW. Blocking it from really working.
What do you think?Antidepressant-Like Behavioral Effects
Mediated by 5-Hydroxytryptamine(2C) Receptors
by
Cryan JF, Lucki I
Department of Psychiatry,
University of Pennsylvania,
Philadelphia, Pennsylvania.
J Pharmacol Exp Ther 2000 Dec 1;295(3):1120-1126ABSTRACT
The role of the 5-HT(2C) receptor in mediating active behaviors in the modified rat forced swim test was examined. Three novel selective 5-HT(2C) receptor agonists, WAY 161503 (0.1-3.0 mg/kg), RO 60-0175 (2-20 mg/kg), and RO 60-0332 (20 mg/kg), all decreased immobility and increased swimming, a pattern of behavior similar to that which occurs with the selective serotonin reuptake inhibitor fluoxetine (5-20 mg/kg). However, the prototypical but nonselective 5-HT(2C) receptor agonist m-chlorophenylpiperazine (1-10 mg/kg) increased immobility scores in the forced swim test. The selective 5-HT(2C) receptor antagonist SB 206533 was inactive when given alone (1-20 mg/kg). However, ****SB 206533 (20 mg/kg) blocked the antidepressant-like effects of both WAY 161503 (1 mg/kg) and fluoxetine (20 mg/kg)****. The atypical antidepressant (noradrenergic alpha(2) and 5-HT(2C) receptor antagonist) mianserin [note that mianserin possesses the exact same qualities as Remeron; it affects the same receptors in the same way] reduced immobility and increased climbing at 30 mg/kg. At a behaviorally subactive dose (10 mg/kg), mianserin abolished the effects of WAY 161503 (1 mg/kg) on both swimming and immobility scores. Mianserin blocked the effects of fluoxetine (20 mg/kg) on swimming only; mianserin plus fluoxetine reduced immobility and induced a switch to climbing behavior, suggesting activation of noradrenergic transmission. These data exemplify the benefits of using the modified rat forced swim test, which was sensitive to serotonergic compounds and distinguished behavioral changes associated with serotonergic and noradrenergic effects. Taken together, the results strongly implicate a role for 5-HT(2C) receptors in the behavioral effects of antidepressant drugs.
poster:McPac
thread:257255
URL: http://www.dr-bob.org/babble/alter/20030903/msgs/257279.html