Posted by tealady on October 11, 2003, at 0:27:02
Hi Lar,
Hoping to borrow your brain again, if you have some spare time ever?I came acros this post last week in trying to work out my B12 reactions...
"Injectable B12 is the main problem as it is stored in the liver and if one has altered CP450 enzymes, you can get toxicity( mainly skin problems ), but as for oral, there is no adverse effect. B6 toxicity can cause a peripheral neuritis, but not B12, You are correct...it is a deficiency of B12 that presents as neuritis"
from Larrian in http://forums.about.com/ab-thyroid/messages?msg=39781.22
I did a pubmed search on "hydroxycobalamin liver enzyme".....http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?http://www.jbc.org/cgi/pmidlookup?view=reprint&pmid=1657942 (full pdf atrticle)
Krahenbuhl S, Chang M, Brass EP, Hoppel CL.
Decreased activities of ubiquinol:ferricytochrome c oxidoreductase (complex III) and ferrocytochrome c:oxygen oxidoreductase (complex IV) in liver mitochondria from rats with hydroxycobalamin[c-lactam]-induced methylmalonic aciduria.
J Biol Chem. 1991 Nov 5;266(31):20998-1003.
PMID: 1657942 [PubMed - indexed for MEDLINE]The pubmed serach also comes up with 12 other studies..but I think this looks the most relevant..
What is it saying please??
I'm thinking perhaps I should not take any more injections?..just import the methylcobalmin from the US...the iherb postage went up from US$20 to US$40 !!!!(not for Canada though)
Thanks , Jan
poster:tealady
thread:268166
URL: http://www.dr-bob.org/babble/alter/20031003/msgs/268166.html