Posted by Larry Hoover on November 30, 2003, at 7:45:14
In reply to temporal lobe, my psychatrist and pospholipides » DSCH, posted by Francesco on November 28, 2003, at 17:12:35
> I told him also about my experiments with aminos and supplements. He seemed interested and he had nothing to object to tyrosine, triptophan or epa/dha but I said that there is no way that pospoliphides can help because of the BBB.
> Any comment or confutation ?I'm glad your pdoc doesn't object to food supplements. It's not like you're taking herb-based drugs....
What I can't comprehend is his position that phospholipids are blocked by the BBB. I can't say whether the intact phospholipids are carried in the blood (they are created in huge amounts by liver, using the blood coming up from the intestines (portal veinous flow) which is full of all the nutrients), or if they're broken down and reassembled later....but it is a purely physical process...
No active transport into brain tissue is required for fat-soluble substances....the membranes that surround all brain cells have cholesterol embedded in a fatty membrane (the so-called lipid bylayer (lipids are fats)). And cholesterol floats around in the blood with dissolved fatty stuff in little blobs....A fatty cholesterol blob in the blood bumps into a fatty brain cell membrane, and lipid components just move naturally from one fatty place to the other....
That said, there are receptors for phosphatidylinositol and perhaps for phosphatidylserine, and there might be uptake pumps for both.....
Anyway, I don't understand what your shrink is thinking....
Lar
poster:Larry Hoover
thread:283254
URL: http://www.dr-bob.org/babble/alter/20031122/msgs/285184.html