Posted by Larry Hoover on July 8, 2004, at 9:55:49
In reply to Re: SAMe » Larry Hoover, posted by Emme on July 7, 2004, at 21:26:09
>
> > I really am leary of SAMe. Most often, it is the tosylate salt. Tosylate is a simplified form of the actual chemical name, toluene-sulfonic acid. I don't like the idea that people are taking toluene-sulfonic acid.
>
> Is another salt of SAM-e preferable?I believe that there is a tert-butyl salt. Also a butane disulphanate. I see no risk in the alternatives.
Here is a sample from a tosylate supplier:
Which SAM-e should you take?
Be sure to look for SAMe in enteric coated tablet form. Enteric coating ensures the proper and safe absorption of supplemental SAMe by the body. SAM e is available in two salt forms, tosylate and butane disulphanate. While both are stable, the tosylate form is backed by over twenty years of research for safety and effectiveness. In addition the tosylate form is widely used in pharmaceutical products. Nature's Rx, Inc. offers only the tosylate form of SAMe because of it's proven safety record. Nature's Rx enteric coated SAMe tablets are double sealed in a brown plastic bottle for optimum quality, freshness and convenience.> What is worse about toluene-sulfonic acid than other forms?
I just don't see that any intake of toluene-sulfonic acid is justified. It's a totally synthetic material (i.e. we have no natural way to detoxify it, except by fluke), and it has no known health benefits. Quite the contrary. I have never heard of any toluene compound that is safe.
Really, you need to take the following with a grain of salt, as it deals with acute exposure to large amounts of the acid form (not the salt), but still....
From the Material Safety Data Sheet for toluene-sulfonic acid:
Potential Health Effects
----------------------------------Information on the human health effects from exposure to this substance is limited.
Inhalation:
Corrosive. Extremely destructive to tissues of the mucous membranes and upper respiratory tract. Symptoms may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea and vomiting. Inhalation may be fatal as a result of spasm inflammation and edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema.
Ingestion:
Extremely destructive to tissues. May be fatal.
Skin Contact:
Extremely destructive to skin. Causes irritation, redness, pain, and burns.
Eye Contact:
Extremely destructive to eyes. Causes irritation, redness, pain, and burns.
Chronic Exposure:
No information found.
Aggravation of Pre-existing Conditions:
No information found.
> > Niacinamide, 500 mg, is my advice.
>
> Wow. 100 mg was too much and 50 mg puts me out.Thanks for letting me know. I suppose, if Bob permitted signature lines, mine would be something like: "Dosage and scheduling guidelines are simple starting points for determining your own tolerance. Your brain/body may vary."
Lar
poster:Larry Hoover
thread:363652
URL: http://www.dr-bob.org/babble/alter/20040613/msgs/364000.html