Posted by Dr. Bob on July 20, 2004, at 10:04:29
In reply to and St. John's Wort is one of them « 1980Monroe, posted by Dr. Bob on July 19, 2004, at 1:48:30
Re: Dr. Bob, please dont redirect the post above » linkadge
Posted by Larry Hoover on July 19, 2004, at 10:22:45
In reply to Re: Dr. Bob, please dont redirect the post above, posted by linkadge on July 18, 2004, at 19:36:26
> you're not exaclty right about St. Johns' wort. It may not have worked for you but, in the latest and *largest* trial both SJW and sertraline were less effective than the placebo, but SJW was more effective than sertraline in this case.
There were so many methodological flaws in that particular study, the results are literally worthless, other than for the headlines which resulted from it. I think it is of especial noteworthiness that not one headline trumpeted the superiority of placebo over the active comparator, sertraline (Zoloft). I personally have never been so disappointed in being a scientist as when I reviewed the methodology and results of this particular study. It was a political act, masquerading as science. I'm still ashamed.
> The SJw debate is not so clear cut.
There was only one study, ever, which used 1800 mg SJW to treat DSM-diagnosed severe depression in an inpatient population, against the active comparator imipramine (often considered to be the work-horse fall-back drug for inpatient severely depressed subjects). The outcomes were identical, but SJW was far better tolerated.
> Personally I think that trimipramine would be ineffective as a sole antidepreessant.
>
>
> LinakdgeTrimipramine is an excellent adjunctive med, however. It has profound histaminic activity, and promotes sleep, without that hangover-like effect seen with trazodone.
Lar
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Re: and St. John's Wort is one of them..... » 1980Monroe
Posted by Larry Hoover on July 19, 2004, at 10:23:20
In reply to and St. John's Wort is one of them....., posted by 1980Monroe on July 18, 2004, at 18:56:56
> I read in one article that is the same a placebo.
One flawed article.
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Re: ineffective medications
Posted by linkadge on July 19, 2004, at 18:32:27
In reply to ineffective medications » SLS, posted by cpallen79 on July 19, 2004, at 17:03:31
Personnaly I found SJW one of the most effective antidpersssants I have ever tried. No apathy, and virtually no side effects. However the inconsistancy in the preparation I was taking made for unpredicatable moods.
Linkadge--
Re: ineffective medications Linkadge
Posted by 1980Monroe on July 19, 2004, at 21:14:05
In reply to Re: ineffective medications, posted by linkadge on July 19, 2004, at 18:32:27
Well Linkadge
I'm glad to hear that , i did a trial about a year ago with it, and i waited for about 8-9weeks and still no results, and i took high doses, like 2100mg+ i stoped after taht because i started getting badly sunburned which i heard is a side effect.
That is really shocking that you claim it is the most effective, i guess it deals diffrent people.......
Later
Matt
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Re: ineffective medications » linkadge
Posted by Larry Hoover on July 20, 2004, at 9:34:04
In reply to Re: ineffective medications, posted by linkadge on July 19, 2004, at 18:32:27
> Personnaly I found SJW one of the most effective antidpersssants I have ever tried. No apathy, and virtually no side effects. However the inconsistancy in the preparation I was taking made for unpredicatable moods.
>
>
> LinkadgeMy experience was the same. The best antidepressant I ever used, bar none. I wish I never discontinued it, as I have not had the same response in more recent trials.
Lar
poster:Dr. Bob
thread:367643
URL: http://www.dr-bob.org/babble/alter/20040718/msgs/368186.html