Posted by raybakes on September 22, 2004, at 12:16:43
In reply to Re: Staying up all night as AD-raybakes? Larry? any? » raybakes, posted by karaS on September 22, 2004, at 10:27:53
>Also, how does your theory of inflammation being at the root of depression correlate with the use of antidepressants? If your theory is correct, then shouldn't antidepressants be useless? (probably I just don't know enough to understand the connection
Not sure about the ins and outs of high or low cortisol, but it does seem that depression can result from either high or low cortisol, so maybe saying dysregulation of the hpa axis is related to depression might be more accurate?
There are a few studies that show antidepressants have an antiinflammatory effect if given for a longer duration, so there's still hope for the theory!..here's one...
Effects of repeated fluoxetine and citalopram administration on cytokine release in C57BL/6 mice.
Kubera M, Simbirtsev A, Mathison R, Maes M.
Department of Endocrinology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland.
This study examines the effects of repeated administration of the selective serotonin reuptake inhibitors (SSRIs), fluoxetine and citalopram (10 mg/kg, i.p.), on immunoreactivity in C57BL/6 mice. Immune functions were evaluated by the ability of splenocytes to reduce a tetrazolium salt to formazan (MTT test), to proliferate, and to produce cytokines, including interleukin (IL)-1, IL-2, IL-4, IL-6, IL-10 and interferon gamma (IFN gamma). Citalopram administered for 1, 2 and 4 weeks stimulates the proliferative activity of splenocytes and suppresses their ability to secrete the anti-inflammatory cytokine IL-4. Fluoxetine administration for 1 and 2 weeks, but not 4 weeks, stimulates the proliferative activity of splenocytes, whereas a 4-week administration of fluoxetine suppresses the secretion of IL-4. Four weeks of prolonged administration of citalopram and fluoxetine induces a significant increase in the production of IL-6 and IL-10, a cytokine with immunosuppressive and anti-inflammatory activities. The results show that, in C57BL/6 mice, the immunomodulatory effects of SSRIs depend on the SSRI used and the duration of administration.
poster:raybakes
thread:391316
URL: http://www.dr-bob.org/babble/alter/20040901/msgs/393695.html